TraumaShield
FDA-approved agent·Novel second medical use·Post-trauma intervention·Fear-memory consolidation modulation·Critical window deployment·PTSD prevention·Medical device + pharma convergence·IP protected·505(b)(2) pathway·FDA-approved agent·Novel second medical use·Post-trauma intervention·Fear-memory consolidation modulation·Critical window deployment·PTSD prevention·Medical device + pharma convergence·IP protected·505(b)(2) pathway·
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Science & Technology

Mechanism, not hope.

An FDA-approved agent, delivered by a field-ready device, acting on the fear-memory consolidation window. Below: how it works, what it is made of, and the evidence behind it.

Mechanism of action Device architecture Clinical validation IP & pathway
Scientific validation

Mechanism of action

Memories are consolidated — not formed — in the hours after trauma. TraumaShield acts on five pathways during that window. Select a pathway to load its model.

Mechanism of action model
Model · Amygdala and hippocampus

Suppresses fear-learning responses (by reducing hyperactivity in the amygdala).

Enhances healthy contextual memory (by enhancing hippocampal neuroplasticity).

Enhances GABAergic inhibitory transmission.

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Suppresses excitatory NMDA receptor activity.

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Modulates neuroprotective pathways to prevent long-term damage.

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Pathological versus historical memory consolidation
The device

Real-time drug‑device intervention for post‑trauma disorder prevention

Time

Administered during the post-trauma “golden hours” to support healthy memory consolidation.

Drug

An FDA-approved, repurposed compound that helps the brain store the event as a past, safe memory instead of an ongoing nightmare.

Device

Delivered through a dedicated, disposable, easy-to-use field device.

TraumaShield drug-device combination — the world's first PTSD prevention protocol
Peer-reviewed evidence

Significant reduction in PTSD incidence.
Peer-reviewed.

Human data
TraumaShield
Standard care
~45%
Reduction in PTSD · p < 0.05
Preclinical data · SEFL models · freezing behavior
~20%
Treated
~80%
Control

Stress-Enhanced Fear Learning (SEFL) significantly reduced in animal models.

Independent peer-reviewed study · reference available to qualified partners.

01 · Mechanism
Fear-memory consolidation window

The neuroscientific mechanism explaining why the 0-6 hour window is the critical prevention point. Memories are consolidated — not formed — in this window, making pharmacological intervention uniquely effective.

02 · Safety
FDA-approved agent

An existing safety profile removes the need for a traditional Phase I program. The repurposed agent has a well-characterized pharmacokinetic and safety profile from prior clinical use.

03 · Evidence
Second medical use, clinically supported

Backed by independent peer-reviewed studies. Significant reduction confirmed in independent human data. Reproduced in preclinical models.

"Backed by independent clinical validation and a full scientific package assembled by world-leading experts in psychiatry and neuroscience."
Strategic moats

Protected, fast,
field-ready.

A method-of-use patent, an accelerated regulatory pathway, and a form factor built for the field — three defenses that compound.

Patent protected
Method-of-Use Patent Filed

Protection filed for the second medical use and the combination device architecture.

Regulatory pathway
505(b)(2) Combination Product

Streamlined FDA pathway defined and pre-IND package prepared, leveraging existing safety data to accelerate time-to-market.

Deployment
Field-ready by design

Engineered for standard IFAK kits and minimal training.

The full scientific
package is available.

Peer-reviewed studies, preclinical datasets and the regulatory dossier are shared with qualified investors and clinical partners on request.

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TraumaShield

Protection begins in the golden hours. TraumaShield is developing the first preventive intervention for post-traumatic stress disorder.

Phase II ready
Site
About Science & Technology Team Investment Contact
Materials
Shareholder documents
Contact
david@traumashield.co

Direct lines to the founding team are released to qualified investors on request.

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© 2026 TraumaShield LTD. · All rights reserved

This website contains forward-looking statements that reflect current expectations and are subject to risks and uncertainties. Nothing on this site constitutes an offer to sell, or a solicitation of an offer to buy, any securities. TraumaShield’s product candidate is in clinical development and has not been approved by the FDA or any other regulatory authority.

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New PTSD cases since you arrived.
Their suffering could have been prevented.

We must act now Act
Mechanism of action model